Next to its well-known effects on cellular growth and repair, human growth hormone has been shown to have significant beneficial effects on protein synthesis, fatty acid oxidation and body composition.
Declines in growth hormone production affect us all
As early as in the 1960s, scientists discovered that the regular ups and downs of growth hormone are impaired in both obese and diabetic patients (Yalow. 1965).
Figure 1: The natural growth hormone production is significantly reduced with aging (Corpas. 1993)
Obesity and diabetes are yet not the only reasons for our growth hormone levels to drop. Studies have shown that with advancing age, even men and women with no clinical evidence of pituitary pathology develop significant decreases in GH secretion (Corpas. 1993). Against that background it is not surprising that growth hormone therapy is associated with significant improvements in several health-relevant parameters in the aging population:
The latest reviews clearly confirm these earlier studies and highlight that the therapeutic administration of human growth hormone will also prevent the age-induced decline in collagen expression in the musculotendinous tissue and effectively increase tendon and bone strength (Boesen. 2014).
The number of young(er) individuals with suboptimal growth hormone levels increases
Only recently, researchers from the Cedars-Sinai Medical Center observed that there is a growing number of people being diagnosed with what scientists and doctors call “idiopathic GH deficiency in adults” (Melmed. 2013) – a condition, that is characterized by chronically suppressed growth hormone levels in the absence of pathological triggers or external cause of growth hormone deficiency
Just like older individuals, young people who suffer from idiopathic growth hormone deficiency exhibit somatic changes in body composition, total energy expenditure and fatty acid metabolism that occur in response to the absence of adequate growth hormone levels. Changes that are, just as it is the case in older individuals reversible by the means therapeutic growth hormone supplementation. e treatment as it is now available to everyone with AgeForce’s unique transdermal growth hormone patches.
Over the past decade, the list of scientifically confirmed benefits of growth hormone therapy has expanded. As of now, the following benefits have been scientifically confirmed (Carroll. 1998):
While previous research focused almost completely on physiological benefits, the psychological and cognitive benefits of growth hormone therapy have gained more and more attention within the scientific community over the past decade. Van Dam et al. highlight that
“[…b]ased on the available data, one might hypothesize that relative GH or IGF-I deficiency could contribute to the deterioration of cognitive functions observed in the elderly.” (Van Dam. 2000)
Due to the complex interactions between human growth hormone and the neuro-endocrine axis, experts expect to find further neurological benefits in future trials. Only recenty, Nyberg & Halberg speculated that growth hormone “might interact with specific receptors located in areas of the CNS that are associated with the functional anatomy of these behaviours” (Nyberg. 2013) and thus contribute directly to increases in synaptic plasticity and human cognitive capacity in people with and without growth hormone deficiency.
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